Depression can be a serious condition that can render a person disabled in their work, with family and in their social life. It can range from mild (feeling discouraged) to severe (feelings of hopelessness). Other symptoms of depression range from changes in appetite to a lack of concentration and shorter attention span. Life with kidney disease and its treatment can be upsetting, especially in the early weeks and months. Most patients and families go through a crisis period as they adjust to complex feelings and make needed changes to their lifestyle.